Hypoxia and Medicine

Why cellular hypoxia cause bradycardia and abolition of pacemaker activity?

Why cellular hypoxia depolarizes the membrane potential causing bradycardia and abolition of pacemaker activity? Because I figure it should accelerate heart rate so called tachycardia?

Public Comments

1. cus it be dope, yo
2. Well hypoxia is a lack of oxygen. Technically speaking if the body is deprived of oxygen for long periods of time it starts to basically shut down. For instance if you can;t breath then basically you will die. Bradycardia becomes an onset of this because ischemia which leads to bradycardia thereby causing the abolition of pacemaker activity.
3. Hypoxia doesn't depolarize any membrane potential. When you have hypoxia, the O2 in your body is lower than normal. This triggers chemoreceptors that are sensitive to this level. Ultimately your brain compensates by sending signals to increase your cardiac output (by increasing heart rate) in an attempt to get more oxygen to your body tissues. Hypoxia does not lead to bradycardia.