I saw a short infomercial on CBS in which former newsman Mike Wallace tells the public depression is a "medical disease." What? Only in the rarest cases (e.g., thyroxine deficiency) has it been established a biological origin causes symptoms of depression. Getting treated for clinical depression is important, but if depressive episodes were caused by a biological pathogen (or the popular misnomer "chemical imbalance") meta-analyses done on talk therapy vs drugs would show the effectiveness of talk therapy is zero (not the case). If depression was simply a "medical disease" then combining the two treatment modes would not be more effective than one or the other. The DSM-IV lists this condition as a psychological disorder--a matter of abnormal behavior not a "medical disease." Moreover, despite FDA approval of anti-depressants for demonstrating more efficacy than placebo, there are still indicaters that anti-depressants may work with some people only because of the placebo effect. In truth, the real medical disease can be caused by drug treatments used for depression. The "chemical imbalance" actually occurs when people take anti-depressants (e.g., serotonin remains in the synapse of neuron connections rather than re-uptaking). Drug treatments can lead to Parkinsonisim, cognitive dysfunction, weight gain, agitation, insomnia, and even suicidality (all considered mere side effects according to the literature). Taking several anti-depressants at the same time puts a person at risk for a potentially lethal toxicity lightly labeled "serotonin syndrome." Mike Wallace even says, "It worked for me," but it's bad science to generalize from one case. I guess my question is more: Do you think he's a paid spokesperson for the pharmaceutical industry? If you want some references: http://psycnet.apa.org/?fa=main.doiLanding&doi=10.1037/1522-3736.1.1.12a http://www.abc.net.au/news/newsitems/200504/s1338168.htm Very good article: http://209.85.173.132/search?q=cache:LqzUHKw87HEJ:psychrights.org/Articles/LacasseonDTCAinEHPP.pdf+%22talk+therapy%22+%22just+as+effective%22+drug&hl=en&ct=clnk&cd=7&gl=us Just Google It!: Actually, "medical disease" is not so broad a descriptor because it implies the illness is internal and a matter for the internal medicine field, i.e., requires a medicinal cure (drug) from a medical doctor. Ms Cat: No offense, but you're obviously biased. Do YOU have any graduate school training? Moreover, there is not one shred of evidence in scientific literature that individuals who develop clinical depression have a serotonin "deficiency." That is exactly the kind of misinformation the pharmaceutical company has spread. I challenge you to go to the link below and read some real honest information about the issue. Read this link please: http://209.85.173.132/search?q=cache:LqzUHKw87HEJ:psychrights.org/Articles/LacasseonDTCAinEHPP.pdf+%22talk+therapy%22+%22just+as+effective%22+drug&hl=en&ct=clnk&cd=7&gl=us Ms Cat: YOU are among those who believe you can get out of depression by just taking a pill. There's going to be negative consequences for that, and THAT's what the public is never told, unless you actually listen to all the contraindictions said at the end of those pharamceutical commercials. Ms Cat: You said "some of the side effects are a nuisance but the really bad ones only happen to 1 in a thousand people or less and they go away if you stop taking the drug." Problem 1: Talk to me about the "nuisance" of developing Parkinsonism after you've been on a maintenance dosage for anti-depressants after maybe 20 years (BTW no long term studies required by the FDA to approve these drugs showing no neurological damage occurs with longterm use). Problem 2: When you stop taking anti-depressants the side effects do not simply go away. People typically get WITHDRAWAL from anti-depressants in severity based on how long they took the drugs. That withdrawal is often misinterpreted as a relapse of symptoms of depression. Solution? Put the person back on the drug indefinately. That's called "negative consequences" for trying to treat depression like it's purely the "medical disease" that Mike Wallace is telling the public.